ODCs

Cytoscape Web

Click node...

Denys-Drash syndrome

1 OMIM reference -
1 associated gene
7 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 1

5 OMIM references -
4 associated genes
11 signs/symptoms

Denys-Drash syndrome

Nephroblastoma

WT1	(UniProt - OMIM)		DIS3L2	(UniProt - OMIM)
			H19	(OMIM)
			POU6F2	(UniProt - OMIM)
			WT1	(UniProt - OMIM)


COMMON GENES	WT1

Citations in the biomedical literature:

Denys-Drash syndrome		Nephroblastoma
	Synonym(s): - Drash syndrome - Wilms tumor and pseudohermaphroditism		Synonym(s): - Renal embryonic tumor - Wilms tumor

	Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare gynecologic or obstetric disease - Rare oncologic disease - Rare renal disease - Rare urogenital disease		Classification (Orphanet): - Rare genetic disease

	Classification (ICD10): - Diseases of the genitourinary system -		Classification (ICD10): - Neoplasms -

	Epidemiological data: (no data available)		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: D030321		External references: 5 OMIM references - 1 MeSH reference: D009396


COMMON SIGNS	- Chronic arterial hypertension

Denys-Drash syndrome		Nephroblastoma
	Very frequent - Male pseudohermaphrodism / lack of virilisation - Nephroblastoma / Wilms tumor - Nephrotic syndrome - Proteinuria - Renal disease / nephropathy Occasional - Mixed gonadal dysgenesis		Very frequent - Acute abdominal pain / colic - Kidney / renal neoplasm / tumor / carcinoma / cancer - Neoplasms / tumors Occasional - Aniridia / iris hypoplasia - Fever / chilling - Hematuria / microhematuria - Hepatic / liver neoplasm / tumor / carcinoma / cancer - Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer - Lymphadenopathy / polyadenopathies - Weight loss / loss of appetite / break in weight curve / general health alteration